Sahoo P. Murthy S. Corresponding author. Received Jul 29; Accepted Nov 5. The physical mixtures of drug and both polymers were prepared by using simple mixing technique at the same ratio as solid dispersion. The solid dispersions or physical mixtures were compressed to tablets.
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Sahoo P. Murthy S. Corresponding author. Received Jul 29; Accepted Nov 5. The physical mixtures of drug and both polymers were prepared by using simple mixing technique at the same ratio as solid dispersion. The solid dispersions or physical mixtures were compressed to tablets. The in vitro release profile and the mathematical models indicate that release of verapamil hydrochloride can be effectively controlled from a tablet containing solid dispersions of Eudragit RLPO.
Controlled-release drug delivery systems have the potential of solving these problems. The disease symptoms such as hypertension, ischemic heart disease, asthma, and rheumatoid arthritis exhibit circadian rhythms. For example, blood pressure tends to be lower while asleep and elevated in the early morning. Development of controlled drug delivery system is a better alternative for use of multiple-dose regimen and for treatment of the above-stated diseases 1 , 2. Several approaches have been used in an attempt to sustain the drug release from dosage forms.
The solid dispersion techniques can be used to enhance the dissolution rate of poorly water-soluble drugs as well as to sustain the drug release by choosing appropriate polymers 3 — 7 , 8 , 9. It has been shown that preparation of matrices with insoluble polymers using solid dispersion SD technique is a valuable method in the production of sustained-release products.
Many studies have been conducted in order to investigate the effect of formulation and process variables on drug release from tablets of physical mixtures of drug and polymer. It has been shown that polymer particle size, compaction force, and the presence of soluble or insoluble additives are among the factors affecting drug release from tablets of physical mixtures 10 , However, there are a few studies investigating the effect of these factors on drug release from tablets of SD systems. Khan et al.
Among the polymers, polymethacrylate resins, like Eudragit RS and RL, have been used as film coatings or inert carriers to formulate oral controlled-release delivery systems of nonsteroidal anti-inflammatory drugs 13 , Eudragit RLPO is a polymer synthesized from acrylic and methacrylic acid esters, containing low-level quaternary ammonium groups and insoluble at physiological pH values and capable of swelling.
Upon compression, this material forms a matrix block releasing the host drug through channels created by the gradual leaching of water-soluble PVP component.
Propranolol hydrochloride, diclofenac sodium, ciprofloxacin hydrochloride, and theophylline matrix tablets were prepared previously using various polymers 17 , Verapamil hydrochloride is a calcium channel blocker used as a peripheral vasodilator. Double-distilled water was used throughout the study and all the other chemicals used were of analytical grade.
Two size fractions of the SD system with Eudragit RLPO were obtained by passing half of the residue through sieve number 40 and half through sieve number
Effect of Kollidon® SR on the release of Albuterol Sulphate from matrix tablets
Corresponding author. Received Dec 28; Accepted Feb Sustained release or controlled release products have became popular for the oral administration of such drugs because they give more consistent blood levels. Sustained release or controlled release with zero order release kinetics maintains plasma concentration of such types of drugs at constant level for better effect. The increased need for patient compliance and demand for improved therapeutic efficacy of propranolol Hydrochloride necessitates controlled release drug delivery system with zero order release kinetics. Literature survey indicated a few methods published describing approaches for sustained release formulations of propranolol hydrochloride.
Technical Information: Kollidon SR
Read more Solid Dispersions In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation. Read more Direct Compression Direct compression DC is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.